| # | County | State | Population | Change since 2020 | Unemployment rate |
|---|
| 1 | Eagle County | Colorado | 54,330 | -2.5 % | 3.3 % |
| 2 | Early County | Georgia | 10,444 | -3.8 % | 4.5 % |
| 3 | East Baton Rouge Parish | Louisiana | 453,022 | -0.8 % | 4.2 % |
| 4 | East Carroll Parish | Louisiana | 6,892 | -7.6 % | 13.0 % |
| 5 | East Feliciana Parish | Louisiana | 19,112 | -2.1 % | 4.3 % |
| 6 | Eastland County | Texas | 18,290 | 3.0 % | 5.3 % |
| 7 | Eaton County | Michigan | 109,494 | 0.3 % | 4.7 % |
| 8 | Eau Claire County | Wisconsin | 108,830 | 3.0 % | 2.9 % |
| 9 | Echols County | Georgia | 3,698 | -0.2 % | 2.8 % |
| 10 | Ector County | Texas | 170,022 | 2.9 % | 3.7 % |
| 11 | Eddy County | New Mexico | 61,436 | -1.4 % | 3.2 % |
| 12 | Eddy County | North Dakota | 2,309 | -1.3 % | 2.6 % |
| 13 | Edgar County | Illinois | 16,398 | -2.8 % | 4.1 % |
| 14 | Edgecombe County | North Carolina | 49,124 | 0.5 % | 5.6 % |
| 15 | Edgefield County | South Carolina | 29,455 | 14.9 % | 3.9 % |
| 16 | Edmonson County | Kentucky | 12,635 | 4.2 % | 5.6 % |
| 17 | Edmunds County | South Dakota | 4,027 | 0.8 % | 2.0 % |
| 18 | Edwards County | Illinois | 5,984 | -4.2 % | 4.3 % |
| 19 | Edwards County | Kansas | 2,731 | -5.9 % | 3.3 % |
| 20 | Edwards County | Texas | 1,383 | -2.8 % | 3.1 % |
| 21 | Effingham County | Georgia | 73,148 | 12.9 % | 2.6 % |
| 22 | Effingham County | Illinois | 34,602 | -0.2 % | 3.6 % |
| 23 | El Dorado County | California | 192,823 | 0.9 % | 5.0 % |
| 24 | El Paso County | Texas | 875,784 | 1.2 % | 4.4 % |
| 25 | El Paso County | Colorado | 752,772 | 2.9 % | 4.1 % |
| 26 | Elbert County | Colorado | 29,382 | 12.8 % | 3.4 % |
| 27 | Elbert County | Georgia | 20,152 | 2.6 % | 3.6 % |
| 28 | Elk County | Pennsylvania | 30,124 | -2.8 % | 4.5 % |
| 29 | Elk County | Kansas | 2,436 | -1.6 % | 4.4 % |
| 30 | Elkhart County | Indiana | 207,436 | 0.2 % | 3.9 % |
| 31 | Elko County | Nevada | 54,363 | 1.2 % | 3.8 % |
| 32 | Elliott County | Kentucky | 7,263 | -1.2 % | 7.9 % |
| 33 | Ellis County | Texas | 232,387 | 20.8 % | 3.8 % |
| 34 | Ellis County | Kansas | 29,007 | 0.2 % | 3.0 % |
| 35 | Ellis County | Oklahoma | 3,601 | -4.1 % | 2.6 % |
| 36 | Ellsworth County | Kansas | 6,316 | -1.0 % | 3.2 % |
| 37 | Elmore County | Alabama | 91,042 | 3.5 % | 2.3 % |
| 38 | Elmore County | Idaho | 29,729 | 3.7 % | 4.3 % |
| 39 | Emanuel County | Georgia | 23,224 | 2.0 % | 4.1 % |
| 40 | Emery County | Utah | 10,161 | 3.4 % | 4.3 % |
| 41 | Emmet County | Michigan | 33,949 | -0.5 % | 6.2 % |
| 42 | Emmet County | Iowa | 9,162 | -2.4 % | 3.8 % |
| 43 | Emmons County | North Dakota | 3,209 | -2.8 % | 4.5 % |
| 44 | Emporia city | Virginia | 5,402 | -6.1 % | 7.9 % |
| 45 | Erath County | Texas | 44,496 | 4.6 % | 3.6 % |
| 46 | Erie County | New York | 950,602 | -0.4 % | 4.0 % |
| 47 | Erie County | Pennsylvania | 267,750 | -1.2 % | 4.5 % |
| 48 | Erie County | Ohio | 73,841 | -2.3 % | 5.4 % |
| 49 | Escambia County | Florida | 331,275 | 2.9 % | 4.3 % |
| 50 | Escambia County | Alabama | 36,630 | -0.4 % | 3.5 % |
| 51 | Esmeralda County | Nevada | 720 | -1.5 % | 7.3 % |
| 52 | Essex County | New Jersey | 881,527 | 2.2 % | 6.3 % |
| 53 | Essex County | Massachusetts | 823,938 | 1.7 % | 4.6 % |
| 54 | Essex County | New York | 36,744 | -1.7 % | 3.6 % |
| 55 | Essex County | Virginia | 10,683 | 0.8 % | 4.2 % |
| 56 | Essex County | Vermont | 6,037 | 2.0 % | 3.6 % |
| 57 | Estill County | Kentucky | 14,002 | -1.1 % | 5.9 % |
| 58 | Etowah County | Alabama | 103,207 | -0.2 % | 3.0 % |
| 59 | Eureka County | Nevada | 1,877 | 1.3 % | 5.7 % |
| 60 | Evangeline Parish | Louisiana | 31,745 | -1.8 % | 4.8 % |
| 61 | Evans County | Georgia | 10,869 | 0.9 % | 3.1 % |