| # | County | State | Population | Change since 2020 | Unemployment rate |
|---|---|---|---|---|---|
| 1 | Quay County | New Mexico | 8,403 | -3.9 % | 3.9 % |
| 2 | Queen Anne's County | Maryland | 53,688 | 7.6 % | 3.1 % |
| 3 | Queens County | New York | 2,316,841 | -3.7 % | 4.7 % |
| 4 | Quitman County | Mississippi | 5,542 | -10.2 % | 5.0 % |
| 5 | Quitman County | Georgia | 2,323 | 4.0 % | 6.8 % |