| # | County | State | Population | Change since 2020 | Unemployment rate |
| 1 | Dade County | Georgia | 16,068 | -1.1 % | 3.3 % |
| 2 | Dade County | Missouri | 7,622 | 0.7 % | 3.8 % |
| 3 | Daggett County | Utah | 956 | 2.1 % | 3.8 % |
| 4 | Dakota County | Minnesota | 453,156 | 3.0 % | 3.6 % |
| 5 | Dakota County | Nebraska | 21,335 | -1.2 % | 3.4 % |
| 6 | Dale County | Alabama | 50,067 | 1.5 % | 3.2 % |
| 7 | Dallam County | Texas | 7,526 | 5.5 % | 2.8 % |
| 8 | Dallas County | Texas | 2,656,028 | 1.7 % | 4.1 % |
| 9 | Dallas County | Iowa | 115,343 | 15.6 % | 3.1 % |
| 10 | Dallas County | Alabama | 35,545 | -7.6 % | 4.6 % |
| 11 | Dallas County | Missouri | 17,877 | 4.7 % | 4.8 % |
| 12 | Dallas County | Arkansas | 6,076 | -6.2 % | 4.2 % |
| 13 | Dane County | Wisconsin | 588,347 | 4.8 % | 2.6 % |
| 14 | Daniels County | Montana | 1,625 | -1.9 % | 2.4 % |
| 15 | Danville city | Virginia | 41,993 | -1.4 % | 5.5 % |
| 16 | Dare County | North Carolina | 38,183 | 3.4 % | 4.3 % |
| 17 | Darke County | Ohio | 51,462 | -0.8 % | 4.4 % |
| 18 | Darlington County | South Carolina | 62,425 | -0.8 % | 5.0 % |
| 19 | Dauphin County | Pennsylvania | 293,029 | 2.3 % | 4.4 % |
| 20 | Davidson County | Tennessee | 729,505 | 1.9 % | 3.0 % |
| 21 | Davidson County | North Carolina | 177,809 | 5.3 % | 3.8 % |
| 22 | Davie County | North Carolina | 45,383 | 6.3 % | 3.6 % |
| 23 | Daviess County | Kentucky | 104,457 | 1.1 % | 4.2 % |
| 24 | Daviess County | Indiana | 34,097 | 2.1 % | 2.9 % |
| 25 | Daviess County | Missouri | 8,541 | 1.3 % | 3.3 % |
| 26 | Davis County | Utah | 378,470 | 4.4 % | 3.3 % |
| 27 | Davis County | Iowa | 9,193 | 0.9 % | 3.3 % |
| 28 | Davison County | South Dakota | 19,907 | -0.2 % | 1.8 % |
| 29 | Dawes County | Nebraska | 8,003 | -2.4 % | 2.9 % |
| 30 | Dawson County | Georgia | 33,748 | 25.9 % | 2.7 % |
| 31 | Dawson County | Nebraska | 24,554 | 1.9 % | 2.9 % |
| 32 | Dawson County | Texas | 11,758 | -5.6 % | 4.2 % |
| 33 | Dawson County | Montana | 8,731 | -2.4 % | 2.7 % |
| 34 | Day County | South Dakota | 5,408 | -0.7 % | 2.4 % |
| 35 | De Baca County | New Mexico | 1,657 | -2.4 % | 4.4 % |
| 36 | De Soto Parish | Louisiana | 27,274 | 1.7 % | 4.7 % |
| 37 | De Witt County | Illinois | 15,319 | -1.3 % | 3.9 % |
| 38 | Deaf Smith County | Texas | 18,495 | -0.5 % | 3.4 % |
| 39 | Dearborn County | Indiana | 51,435 | 1.5 % | 3.5 % |
| 40 | Decatur County | Georgia | 29,391 | 0.1 % | 3.6 % |
| 41 | Decatur County | Indiana | 26,421 | -0.2 % | 3.5 % |
| 42 | Decatur County | Tennessee | 11,800 | 3.2 % | 4.6 % |
| 43 | Decatur County | Iowa | 7,656 | -1.4 % | 3.3 % |
| 44 | Decatur County | Kansas | 2,716 | -1.3 % | 3.2 % |
| 45 | Deer Lodge County | Montana | 9,811 | 4.1 % | 4.0 % |
| 46 | Defiance County | Ohio | 38,644 | 0.9 % | 4.5 % |
| 47 | DeKalb County | Georgia | 770,307 | 0.8 % | 3.6 % |
| 48 | DeKalb County | Illinois | 101,335 | 0.8 % | 4.5 % |
| 49 | DeKalb County | Alabama | 73,122 | 2.1 % | 2.5 % |
| 50 | DeKalb County | Indiana | 44,330 | 2.4 % | 3.3 % |
| 51 | DeKalb County | Tennessee | 21,747 | 8.3 % | 4.1 % |
| 52 | DeKalb County | Missouri | 9,884 | -10.4 % | 4.3 % |
| 53 | Del Norte County | California | 27,009 | -2.6 % | 6.4 % |
| 54 | Delaware County | Pennsylvania | 584,882 | 1.4 % | 4.2 % |
| 55 | Delaware County | Ohio | 237,966 | 11.1 % | 3.8 % |
| 56 | Delaware County | Indiana | 112,951 | 0.9 % | 4.1 % |
| 57 | Delaware County | New York | 44,191 | -0.3 % | 4.2 % |
| 58 | Delaware County | Oklahoma | 41,771 | 3.4 % | 3.6 % |
| 59 | Delaware County | Iowa | 17,609 | 0.7 % | 3.1 % |
| 60 | Delta County | Michigan | 36,687 | -0.6 % | 6.5 % |
| 61 | Delta County | Colorado | 32,215 | 3.3 % | 5.4 % |
| 62 | Delta County | Texas | 5,647 | 8.1 % | 4.1 % |
| 63 | Denali Borough | Alaska | 1,621 | -0.2 % | 4.9 % |
| 64 | Dent County | Missouri | 14,721 | 2.1 % | 4.0 % |
| 65 | Denton County | Texas | 1,045,120 | 15.3 % | 3.8 % |
| 66 | Denver County | Colorado | 729,019 | 1.9 % | 4.1 % |
| 67 | Des Moines County | Iowa | 38,411 | -1.4 % | 4.2 % |
| 68 | Deschutes County | Oregon | 211,535 | 6.7 % | 4.8 % |
| 69 | Desha County | Arkansas | 10,321 | -9.4 % | 7.2 % |
| 70 | DeSoto County | Mississippi | 195,871 | 5.7 % | 3.6 % |
| 71 | DeSoto County | Florida | 36,744 | 8.2 % | 4.9 % |
| 72 | Deuel County | South Dakota | 4,335 | 0.8 % | 2.5 % |
| 73 | Deuel County | Nebraska | 1,892 | 2.9 % | 3.1 % |
| 74 | Dewey County | South Dakota | 5,322 | 1.5 % | 5.1 % |
| 75 | Dewey County | Oklahoma | 4,268 | -4.7 % | 2.0 % |
| 76 | DeWitt County | Texas | 20,252 | 2.1 % | 4.8 % |
| 77 | Dickens County | Texas | 1,725 | -2.6 % | 3.9 % |
| 78 | Dickenson County | Virginia | 13,411 | -5.1 % | 4.8 % |
| 79 | Dickey County | North Dakota | 4,930 | -1.2 % | 1.9 % |
| 80 | Dickinson County | Michigan | 25,995 | 0.2 % | 5.1 % |
| 81 | Dickinson County | Kansas | 18,621 | 1.2 % | 3.7 % |
| 82 | Dickinson County | Iowa | 18,158 | 2.5 % | 3.4 % |
| 83 | Dickson County | Tennessee | 57,641 | 6.1 % | 3.0 % |
| 84 | Dillingham Census Area | Alaska | 4,642 | -4.4 % | 7.7 % |
| 85 | Dillon County | South Carolina | 27,577 | -2.5 % | 6.0 % |
| 86 | Dimmit County | Texas | 8,181 | -5.0 % | 7.0 % |
| 87 | Dinwiddie County | Virginia | 28,576 | 2.3 % | 3.4 % |
| 88 | District of Columbia | District of Columbia | 702,250 | 1.8 % | 6.3 % |
| 89 | Divide County | North Dakota | 2,124 | -3.2 % | 2.1 % |
| 90 | Dixie County | Florida | 17,614 | 5.1 % | 5.1 % |
| 91 | Dixon County | Nebraska | 5,526 | -1.3 % | 2.7 % |
| 92 | Doddridge County | West Virginia | 7,615 | -2.5 % | 3.7 % |
| 93 | Dodge County | Wisconsin | 88,635 | -0.8 % | 2.7 % |
| 94 | Dodge County | Nebraska | 37,884 | 1.9 % | 3.0 % |
| 95 | Dodge County | Minnesota | 21,242 | 1.8 % | 3.8 % |
| 96 | Dodge County | Georgia | 19,630 | -1.9 % | 3.4 % |
| 97 | Dolores County | Colorado | 2,467 | 6.1 % | 4.2 % |
| 98 | Doniphan County | Kansas | 7,575 | 1.0 % | 4.0 % |
| 99 | Donley County | Texas | 3,193 | -2.1 % | 4.2 % |
| 100 | Dooly County | Georgia | 11,186 | -0.2 % | 3.7 % |
| 101 | Door County | Wisconsin | 30,512 | 1.5 % | 3.4 % |
| 102 | Dorchester County | South Carolina | 174,663 | 8.3 % | 3.9 % |
| 103 | Dorchester County | Maryland | 33,138 | 1.9 % | 4.4 % |
| 104 | Dougherty County | Georgia | 82,418 | -3.9 % | 4.9 % |
| 105 | Douglas County | Nebraska | 601,158 | 2.8 % | 3.3 % |
| 106 | Douglas County | Colorado | 393,995 | 10.1 % | 3.7 % |
| 107 | Douglas County | Georgia | 151,887 | 5.2 % | 3.7 % |
| 108 | Douglas County | Kansas | 121,989 | 2.7 % | 3.5 % |
| 109 | Douglas County | Oregon | 112,255 | 0.9 % | 6.2 % |
| 110 | Douglas County | Nevada | 49,564 | 0.2 % | 4.3 % |
| 111 | Douglas County | Washington | 45,795 | 6.7 % | 5.2 % |
| 112 | Douglas County | Wisconsin | 44,276 | -0.0 % | 4.6 % |
| 113 | Douglas County | Minnesota | 39,933 | 2.4 % | 3.6 % |
| 114 | Douglas County | Illinois | 19,824 | 0.4 % | 3.7 % |
| 115 | Douglas County | Missouri | 12,290 | 6.2 % | 4.7 % |
| 116 | Douglas County | South Dakota | 2,849 | 0.6 % | 1.9 % |
| 117 | Doña Ana County | New Mexico | 229,366 | 4.5 % | 4.9 % |
| 118 | Drew County | Arkansas | 16,935 | -2.4 % | 5.0 % |
| 119 | Dubois County | Indiana | 43,629 | -0.0 % | 2.9 % |
| 120 | Dubuque County | Iowa | 99,242 | -0.0 % | 3.5 % |
| 121 | Duchesne County | Utah | 20,803 | 6.1 % | 3.8 % |
| 122 | Dukes County | Massachusetts | 21,061 | 2.3 % | 5.3 % |
| 123 | Dundy County | Nebraska | 1,581 | -4.4 % | 2.0 % |
| 124 | Dunklin County | Missouri | 27,002 | -4.5 % | 5.5 % |
| 125 | Dunn County | Wisconsin | 46,135 | 1.5 % | 3.4 % |
| 126 | Dunn County | North Dakota | 4,031 | -1.6 % | 2.6 % |
| 127 | DuPage County | Illinois | 937,142 | 0.4 % | 3.9 % |
| 128 | Duplin County | North Carolina | 50,539 | 3.8 % | 3.3 % |
| 129 | Durham County | North Carolina | 343,628 | 5.8 % | 3.4 % |
| 130 | Dutchess County | New York | 299,963 | 1.0 % | 3.3 % |
| 131 | Duval County | Florida | 1,055,159 | 6.0 % | 4.1 % |
| 132 | Duval County | Texas | 9,585 | -2.5 % | 4.6 % |
| 133 | Dyer County | Tennessee | 36,403 | -1.1 % | 3.5 % |